Positron emission tomography response evaluation from a randomized phase III trial of weekly nab-paclitaxel plus gemcitabine versus gemcitabine alone for patients with metastatic adenocarcinoma of the pancreas†
Identifieur interne : 001931 ( Main/Exploration ); précédent : 001930; suivant : 001932Positron emission tomography response evaluation from a randomized phase III trial of weekly nab-paclitaxel plus gemcitabine versus gemcitabine alone for patients with metastatic adenocarcinoma of the pancreas†
Auteurs : R. K. Ramanathan [États-Unis] ; D. Goldstein [Australie] ; R. L. Korn ; F. Arena [États-Unis] ; M. Moore [Canada] ; S. Siena [Italie] ; L. Teixeira [France] ; J. Tabernero [Espagne] ; J.-L. Van Laethem [Belgique] ; H. Liu ; D. Mcgovern ; B. Lu ; D. D. Von Hoff [États-Unis]Source :
- Annals of Oncology [ 0923-7534 ] ; 2016.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Adénocarcinome (anatomopathologie), Adénocarcinome (imagerie diagnostique), Adénocarcinome (traitement médicamenteux), Albumines (administration et posologie), Calendrier d'administration des médicaments, Désoxycytidine (administration et posologie), Désoxycytidine (analogues et dérivés), Femelle, Humains, Mâle, Métastase tumorale, Paclitaxel (administration et posologie), Protocoles de polychimiothérapie antinéoplasique (administration et posologie), Résultat thérapeutique, Sujet âgé, Sujet âgé de 80 ans ou plus, Survie sans rechute, Tomographie par émission de positons, Tumeurs du pancréas (anatomopathologie), Tumeurs du pancréas (imagerie diagnostique), Tumeurs du pancréas (traitement médicamenteux).
- MESH :
- administration et posologie : Albumines, Désoxycytidine, Paclitaxel, Protocoles de polychimiothérapie antinéoplasique.
- analogues et dérivés : Désoxycytidine.
- anatomopathologie : Adénocarcinome, Tumeurs du pancréas.
- imagerie diagnostique : Adénocarcinome, Tumeurs du pancréas.
- traitement médicamenteux : Adénocarcinome, Tumeurs du pancréas.
- Adulte, Adulte d'âge moyen, Calendrier d'administration des médicaments, Femelle, Humains, Mâle, Métastase tumorale, Résultat thérapeutique, Sujet âgé, Sujet âgé de 80 ans ou plus, Survie sans rechute, Tomographie par émission de positons.
English descriptors
- KwdEn :
- Adenocarcinoma (diagnostic imaging), Adenocarcinoma (drug therapy), Adenocarcinoma (pathology), Adult, Aged, Aged, 80 and over, Albumins (administration & dosage), Antineoplastic Combined Chemotherapy Protocols (administration & dosage), Deoxycytidine (administration & dosage), Deoxycytidine (analogs & derivatives), Disease-Free Survival, Drug Administration Schedule, Female, Humans, Male, Middle Aged, Neoplasm Metastasis, Paclitaxel (administration & dosage), Pancreatic Neoplasms (diagnostic imaging), Pancreatic Neoplasms (drug therapy), Pancreatic Neoplasms (pathology), Positron-Emission Tomography, Treatment Outcome.
- MESH :
- chemical , administration & dosage : Albumins, Deoxycytidine, Paclitaxel.
- administration & dosage : Antineoplastic Combined Chemotherapy Protocols.
- chemical , analogs & derivatives : Deoxycytidine.
- diagnostic imaging : Adenocarcinoma, Pancreatic Neoplasms.
- drug therapy : Adenocarcinoma, Pancreatic Neoplasms.
- pathology : Adenocarcinoma, Pancreatic Neoplasms.
- Adult, Aged, Aged, 80 and over, Disease-Free Survival, Drug Administration Schedule, Female, Humans, Male, Middle Aged, Neoplasm Metastasis, Positron-Emission Tomography, Treatment Outcome.
Abstract
In a phase III pancreatic cancer study, tumor response by positron emission tomography (PET) (exploratory end point) predicted treatment efficacy, including longer overall survival.
Url:
DOI: 10.1093/annonc/mdw020
PubMed: 26802153
PubMed Central: 4803456
Affiliations:
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K." last="Ramanathan">R. K. Ramanathan</name><affiliation wicri:level="1"><nlm:aff id="mdw020_af1"><addr-line>Division of Hematology/Oncology</addr-line>,<institution>Mayo Clinic</institution>,<addr-line>Scottsdale</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Goldstein, D" sort="Goldstein, D" uniqKey="Goldstein D" first="D." last="Goldstein">D. Goldstein</name><affiliation wicri:level="1"><nlm:aff id="mdw020_af2"><addr-line>Department of Medical Oncology</addr-line>,<institution>Prince of Wales Hospital</institution>,<addr-line>Sydney</addr-line>,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Korn, R L" sort="Korn, R L" uniqKey="Korn R" first="R. L." last="Korn">R. L. Korn</name><affiliation><nlm:aff id="mdw020_af3"><addr-line>Diagnostic Radiology</addr-line>,<institution>Scottsdale Medical Imaging, Ltd</institution>,<addr-line>Scottsdale</addr-line></nlm:aff></affiliation></author><author><name sortKey="Arena, F" sort="Arena, F" uniqKey="Arena F" first="F." last="Arena">F. Arena</name><affiliation wicri:level="1"><nlm:aff id="mdw020_af4"><addr-line>Hematology/Oncology</addr-line>,<institution>NYU Langone Arena Oncology</institution>,<addr-line>Lake Success</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Moore, M" sort="Moore, M" uniqKey="Moore M" first="M." last="Moore">M. Moore</name><affiliation wicri:level="1"><nlm:aff id="mdw020_af5"><institution>Provencial Health Services Authority, BC Cancer Agency</institution>,<addr-line>Vancouver</addr-line>,<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Siena, S" sort="Siena, S" uniqKey="Siena S" first="S." last="Siena">S. Siena</name><affiliation wicri:level="1"><nlm:aff id="mdw020_af6"><addr-line>Falck Division of Oncology, Department of Oncology and Hematology</addr-line>,<institution>Niguarda Cancer Center, Ospedale Niguarda Ca’ Granda and Università degli Studi di Millano</institution>,<addr-line>Milan</addr-line>,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Teixeira, L" sort="Teixeira, L" uniqKey="Teixeira L" first="L." last="Teixeira">L. Teixeira</name><affiliation wicri:level="1"><nlm:aff id="mdw020_af7"><addr-line>Department of Medical Oncology</addr-line>,<institution>Hôpital Saint-Antoine</institution>,<addr-line>Paris</addr-line>,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Tabernero, J" sort="Tabernero, J" uniqKey="Tabernero J" first="J." last="Tabernero">J. Tabernero</name><affiliation wicri:level="1"><nlm:aff id="mdw020_af8"><addr-line>Department of Medical Oncology</addr-line>,<institution>Vall d'Hebron University Hospital and Institute of Oncology (VHIO), Universitat Autònoma de Barcelona</institution>,<addr-line>Barcelona</addr-line>,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Van Laethem, J L" sort="Van Laethem, J L" uniqKey="Van Laethem J" first="J.-L." last="Van Laethem">J.-L. Van Laethem</name><affiliation wicri:level="1"><nlm:aff id="mdw020_af9"><institution>University Clinic of Brussels, Hôpital Erasme</institution>,<addr-line>Brussels</addr-line>,<country>Belgium</country></nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Liu, H" sort="Liu, H" uniqKey="Liu H" first="H." last="Liu">H. Liu</name><affiliation><nlm:aff id="mdw020_af10"><institution>Biostatistics and Research and Design, Celgene Corporation</institution>,<addr-line>Summit</addr-line></nlm:aff></affiliation></author><author><name sortKey="Mcgovern, D" sort="Mcgovern, D" uniqKey="Mcgovern D" first="D." last="Mcgovern">D. Mcgovern</name><affiliation><nlm:aff id="mdw020_af10"><institution>Biostatistics and Research and Design, Celgene Corporation</institution>,<addr-line>Summit</addr-line></nlm:aff></affiliation></author><author><name sortKey="Lu, B" sort="Lu, B" uniqKey="Lu B" first="B." last="Lu">B. Lu</name><affiliation><nlm:aff id="mdw020_af10"><institution>Biostatistics and Research and Design, Celgene Corporation</institution>,<addr-line>Summit</addr-line></nlm:aff></affiliation></author><author><name sortKey="Von Hoff, D D" sort="Von Hoff, D D" uniqKey="Von Hoff D" first="D. D." last="Von Hoff">D. D. Von Hoff</name><affiliation wicri:level="1"><nlm:aff id="mdw020_af11"><addr-line>Clinical Research</addr-line>,<institution>Translational Genomics Research Institute and Honor Health</institution>,<addr-line>Scottsdale</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Annals of Oncology</title><idno type="ISSN">0923-7534</idno><idno type="eISSN">1569-8041</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adenocarcinoma (diagnostic imaging)</term><term>Adenocarcinoma (drug therapy)</term><term>Adenocarcinoma (pathology)</term><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Albumins (administration & dosage)</term><term>Antineoplastic Combined Chemotherapy Protocols (administration & dosage)</term><term>Deoxycytidine (administration & dosage)</term><term>Deoxycytidine (analogs & derivatives)</term><term>Disease-Free Survival</term><term>Drug Administration Schedule</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Neoplasm Metastasis</term><term>Paclitaxel (administration & dosage)</term><term>Pancreatic Neoplasms (diagnostic imaging)</term><term>Pancreatic Neoplasms (drug therapy)</term><term>Pancreatic Neoplasms (pathology)</term><term>Positron-Emission Tomography</term><term>Treatment Outcome</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Adénocarcinome (anatomopathologie)</term><term>Adénocarcinome (imagerie diagnostique)</term><term>Adénocarcinome (traitement médicamenteux)</term><term>Albumines (administration et posologie)</term><term>Calendrier d'administration des médicaments</term><term>Désoxycytidine (administration et posologie)</term><term>Désoxycytidine (analogues et dérivés)</term><term>Femelle</term><term>Humains</term><term>Mâle</term><term>Métastase tumorale</term><term>Paclitaxel (administration et posologie)</term><term>Protocoles de polychimiothérapie antinéoplasique (administration et posologie)</term><term>Résultat thérapeutique</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Survie sans rechute</term><term>Tomographie par émission de positons</term><term>Tumeurs du pancréas (anatomopathologie)</term><term>Tumeurs du pancréas (imagerie diagnostique)</term><term>Tumeurs du pancréas (traitement médicamenteux)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Albumins</term><term>Deoxycytidine</term><term>Paclitaxel</term></keywords><keywords scheme="MESH" qualifier="administration & dosage" xml:lang="en"><term>Antineoplastic Combined Chemotherapy Protocols</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Albumines</term><term>Désoxycytidine</term><term>Paclitaxel</term><term>Protocoles de polychimiothérapie antinéoplasique</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Deoxycytidine</term></keywords><keywords scheme="MESH" qualifier="analogues et dérivés" xml:lang="fr"><term>Désoxycytidine</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Adénocarcinome</term><term>Tumeurs du pancréas</term></keywords><keywords scheme="MESH" qualifier="diagnostic imaging" xml:lang="en"><term>Adenocarcinoma</term><term>Pancreatic Neoplasms</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Adenocarcinoma</term><term>Pancreatic Neoplasms</term></keywords><keywords scheme="MESH" qualifier="imagerie diagnostique" xml:lang="fr"><term>Adénocarcinome</term><term>Tumeurs du pancréas</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Adenocarcinoma</term><term>Pancreatic Neoplasms</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Adénocarcinome</term><term>Tumeurs du pancréas</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Disease-Free Survival</term><term>Drug Administration Schedule</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Neoplasm Metastasis</term><term>Positron-Emission Tomography</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Calendrier d'administration des médicaments</term><term>Femelle</term><term>Humains</term><term>Mâle</term><term>Métastase tumorale</term><term>Résultat thérapeutique</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Survie sans rechute</term><term>Tomographie par émission de positons</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>In a phase III pancreatic cancer study, tumor response by positron emission tomography (PET) (exploratory end point) predicted treatment efficacy, including longer overall survival. <italic>nab</italic>-Paclitaxel/gemcitabine had a significantly higher rate of metabolic response versus gemcitabine. Overall, 5× more patients had a metabolic response by PET compared with RECIST. PET may be a more sensitive measure of response than radiographic modalities.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Wood, Ka" uniqKey="Wood K">KA Wood</name></author><author><name sortKey="Hoskin, Pj" uniqKey="Hoskin P">PJ Hoskin</name></author><author><name sortKey="Saunders, Mi" uniqKey="Saunders M">MI Saunders</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Selzner, M" uniqKey="Selzner M">M Selzner</name></author><author><name sortKey="Hany, Tf" uniqKey="Hany T">TF Hany</name></author><author><name sortKey="Wildbrett, P" uniqKey="Wildbrett P">P Wildbrett</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Borst, Gr" uniqKey="Borst G">GR Borst</name></author><author><name sortKey="Belderbos, Js" uniqKey="Belderbos J">JS Belderbos</name></author><author><name sortKey="Boellaard, R" uniqKey="Boellaard R">R Boellaard</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Reske, Sn" uniqKey="Reske S">SN Reske</name></author><author><name sortKey="Grillenberger, Kg" uniqKey="Grillenberger K">KG Grillenberger</name></author><author><name sortKey="Glatting, G" uniqKey="Glatting G">G Glatting</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Young, H" uniqKey="Young H">H Young</name></author><author><name sortKey="Baum, R" uniqKey="Baum R">R Baum</name></author><author><name sortKey="Cremerius, U" uniqKey="Cremerius U">U Cremerius</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Eschmann, Sm" uniqKey="Eschmann S">SM Eschmann</name></author><author><name sortKey="Friedel, G" uniqKey="Friedel G">G Friedel</name></author><author><name sortKey="Paulsen, F" uniqKey="Paulsen F">F Paulsen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Eisenhauer, Ea" uniqKey="Eisenhauer E">EA Eisenhauer</name></author><author><name sortKey="Therasse, P" uniqKey="Therasse P">P Therasse</name></author><author><name sortKey="Bogaerts, J" uniqKey="Bogaerts J">J Bogaerts</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Piessevaux, H" uniqKey="Piessevaux H">H Piessevaux</name></author><author><name sortKey="Buyse, M" uniqKey="Buyse M">M Buyse</name></author><author><name sortKey="Schlichting, M" uniqKey="Schlichting M">M Schlichting</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ott, K" uniqKey="Ott K">K Ott</name></author><author><name sortKey="Herrmann, K" uniqKey="Herrmann K">K Herrmann</name></author><author><name sortKey="Lordick, F" uniqKey="Lordick F">F Lordick</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Haioun, C" uniqKey="Haioun C">C Haioun</name></author><author><name sortKey="Itti, E" uniqKey="Itti E">E Itti</name></author><author><name sortKey="Rahmouni, A" uniqKey="Rahmouni A">A Rahmouni</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Antoch, G" uniqKey="Antoch G">G Antoch</name></author><author><name sortKey="Kanja, J" uniqKey="Kanja J">J Kanja</name></author><author><name sortKey="Bauer, S" uniqKey="Bauer S">S Bauer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Choi, H" uniqKey="Choi H">H Choi</name></author><author><name sortKey="Charnsangavej, C" uniqKey="Charnsangavej C">C Charnsangavej</name></author><author><name sortKey="De Castro Faria, S" uniqKey="De Castro Faria S">S de Castro Faria</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Choi, Hj" uniqKey="Choi H">HJ Choi</name></author><author><name sortKey="Kang, Cm" uniqKey="Kang C">CM Kang</name></author><author><name sortKey="Lee, Wj" uniqKey="Lee W">WJ Lee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Von Hoff, Dd" uniqKey="Von Hoff D">DD Von Hoff</name></author><author><name sortKey="Ramanathan, Rk" uniqKey="Ramanathan R">RK Ramanathan</name></author><author><name sortKey="Borad, Mj" uniqKey="Borad M">MJ Borad</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Goldstein, D" uniqKey="Goldstein D">D Goldstein</name></author><author><name sortKey="El Maraghi, Rh" uniqKey="El Maraghi R">RH El-Maraghi</name></author><author><name sortKey="Hammel, P" uniqKey="Hammel P">P Hammel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Von Hoff, Dd" uniqKey="Von Hoff D">DD Von Hoff</name></author><author><name sortKey="Ervin, T" uniqKey="Ervin T">T Ervin</name></author><author><name sortKey="Arena, Fp" uniqKey="Arena F">FP Arena</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Prior, Jo" uniqKey="Prior J">JO Prior</name></author><author><name sortKey="Montemurro, M" uniqKey="Montemurro M">M Montemurro</name></author><author><name sortKey="Orcurto, Mv" uniqKey="Orcurto M">MV Orcurto</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wu, Aj" uniqKey="Wu A">AJ Wu</name></author><author><name sortKey="Goodman, Ka" uniqKey="Goodman K">KA Goodman</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Australie</li><li>Belgique</li><li>Canada</li><li>Espagne</li><li>France</li><li>Italie</li><li>États-Unis</li></country></list><tree><noCountry><name sortKey="Korn, R L" sort="Korn, R L" uniqKey="Korn R" first="R. L." last="Korn">R. L. Korn</name><name sortKey="Liu, H" sort="Liu, H" uniqKey="Liu H" first="H." last="Liu">H. Liu</name><name sortKey="Lu, B" sort="Lu, B" uniqKey="Lu B" first="B." last="Lu">B. Lu</name><name sortKey="Mcgovern, D" sort="Mcgovern, D" uniqKey="Mcgovern D" first="D." last="Mcgovern">D. Mcgovern</name></noCountry><country name="États-Unis"><noRegion><name sortKey="Ramanathan, R K" sort="Ramanathan, R K" uniqKey="Ramanathan R" first="R. K." last="Ramanathan">R. K. Ramanathan</name></noRegion><name sortKey="Arena, F" sort="Arena, F" uniqKey="Arena F" first="F." last="Arena">F. Arena</name><name sortKey="Von Hoff, D D" sort="Von Hoff, D D" uniqKey="Von Hoff D" first="D. D." last="Von Hoff">D. D. Von Hoff</name></country><country name="Australie"><noRegion><name sortKey="Goldstein, D" sort="Goldstein, D" uniqKey="Goldstein D" first="D." last="Goldstein">D. Goldstein</name></noRegion></country><country name="Canada"><noRegion><name sortKey="Moore, M" sort="Moore, M" uniqKey="Moore M" first="M." last="Moore">M. Moore</name></noRegion></country><country name="Italie"><noRegion><name sortKey="Siena, S" sort="Siena, S" uniqKey="Siena S" first="S." last="Siena">S. Siena</name></noRegion></country><country name="France"><noRegion><name sortKey="Teixeira, L" sort="Teixeira, L" uniqKey="Teixeira L" first="L." last="Teixeira">L. Teixeira</name></noRegion></country><country name="Espagne"><noRegion><name sortKey="Tabernero, J" sort="Tabernero, J" uniqKey="Tabernero J" first="J." last="Tabernero">J. Tabernero</name></noRegion></country><country name="Belgique"><noRegion><name sortKey="Van Laethem, J L" sort="Van Laethem, J L" uniqKey="Van Laethem J" first="J.-L." last="Van Laethem">J.-L. Van Laethem</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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